Application

Ubiquitination Cascade Comoponent: Substrate

Disclaimer

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General description

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.

p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases including; choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.

Legal Information

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UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Physical form

Purified using immobilized metal affinity chromatography.